Enhanced exposure therapy for combat-related Posttraumatic Stress Disorder (PTSD): Study protocol for a randomized controlled trial (bibtex)
by JoAnn Difede, Barbara O. Rothbaum, Albert A. Rizzo, Katarzyna Wyka, Lisa Spielman, Tanja Jovanovic, Christopher Reist, Michael J. Roy, Seth D. Norrholm, Charles Glatt, Francis Lee
Abstract:
Background: PTSD, which has been identified in up to 23\% of post-9-11 veterans, often results in a chronic, pernicious course. Thus, effective treatments are imperative. The Institute of Medicine (IOM) concluded that the only intervention for PTSD with sufficient evidence to conclude efficacy is exposure therapy. This Phase III trial compares the efficacy of exposure therapy for combat-related PTSD delivered in two different formats- via virtual reality exposure therapy (VRE) or prolonged exposure therapy (PE)- combined with D-Cycloserine (DCS), a cognitive enhancer shown to facilitate the extinction of fear.
Reference:
Enhanced exposure therapy for combat-related Posttraumatic Stress Disorder (PTSD): Study protocol for a randomized controlled trial (JoAnn Difede, Barbara O. Rothbaum, Albert A. Rizzo, Katarzyna Wyka, Lisa Spielman, Tanja Jovanovic, Christopher Reist, Michael J. Roy, Seth D. Norrholm, Charles Glatt, Francis Lee), In Contemporary Clinical Trials, 2019.
Bibtex Entry:
@article{difede_enhanced_2019,
	title = {Enhanced exposure therapy for combat-related {Posttraumatic} {Stress} {Disorder} ({PTSD}): {Study} protocol for a randomized controlled trial},
	issn = {15517144},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S1551714419305725},
	doi = {10.1016/j.cct.2019.105857},
	abstract = {Background: PTSD, which has been identified in up to 23\% of post-9-11 veterans, often results in a chronic, pernicious course. Thus, effective treatments are imperative. The Institute of Medicine (IOM) concluded that the only intervention for PTSD with sufficient evidence to conclude efficacy is exposure therapy. This Phase III trial compares the efficacy of exposure therapy for combat-related PTSD delivered in two different formats- via virtual reality exposure therapy (VRE) or prolonged exposure therapy (PE)- combined with D-Cycloserine (DCS), a cognitive enhancer shown to facilitate the extinction of fear.},
	journal = {Contemporary Clinical Trials},
	author = {Difede, JoAnn and Rothbaum, Barbara O. and Rizzo, Albert A. and Wyka, Katarzyna and Spielman, Lisa and Jovanovic, Tanja and Reist, Christopher and Roy, Michael J. and Norrholm, Seth D. and Glatt, Charles and Lee, Francis},
	month = oct,
	year = {2019},
	keywords = {MedVR},
	pages = {105857}
}
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